Protein name:
Cullin-5 (CUL-5) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, the Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS(LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS(SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS(WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS(SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS(SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS(SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS(SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS(RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.
Function:
Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Subcellular Location:
N/A
Protein Attributes:
50:
MATSNLLKNK | GSLQFEDKWD | FMHPIVLKLL | RQESVTKQQW | FDLFSDVHAV |
100:
CLWDDKGSSK | IHQALKEDIL | EFIKQAQARV | LSHQDDTALL | KAYIVEWRKF |
150:
FTQCDILPKP | FCQLEVTLLG | KQSSNKKSNM | EDSIVRKLML | DTWNESIFSN |
200:
IKNRLQDSAM | KLVHAERLGE | AFDSQLVIGV | RESYVNLCSN | PEDKLQIYRD |
250:
NFEKAYLDST | ERFYRTQAPS | YLQQNGVQNY | MKYADAKLKE | EEKRALRYLE |
300:
TRRECNSVEA | LMECCVNALV | TSFKETILAE | CQGMIKRNET | EKLHLMFSLM |
350:
DKVPNGIEPM | LKDLEEHIIS | AGLADMVAAA | ETITTDSEKY | VEQLLTLFNR |
400:
FSKLVKEAFQ | DDPRFLTARD | KAYKAVVNDA | TIFKLELPLK | QKGVGLKTQP |
450:
ESKCPELLAN | YCDMLLRKTP | LSKKLTSEEI | EAKLKEVLLV | LKYVQNKDVF |
500:
MRYHKAHLTR | RLILDISADS | EIEENMVEWL | REVGMPADYV | NKLARMFQDI |
550:
KVSEDLNQAF | KEMHKNNKLA | LPADSVNIKI | LNAGAWSRSS | EKVFVSLPTE |
600:
LEDLIPEVEE | FYKKNHSGRK | LHWHHLMSNG | IITFKNEVGQ | YDLEVTTFQL |
650:
AVLFAWNQRP | REKISFENLK | LATELPDAEL | RRTLWSLVAF | PKLKRQVLLY |
700:
DPQVNSPKDF | TEGTLFSVNQ | DFSLIKNAKV | QKRGKINLIG | RLQLTTERMR |
750:
EEENEGIVQL | RILRTQEAII | QIMKMRKKIS | NAQLQTELVE | ILKNMFLPQK |
780:
KMIKEQMEWL | IEHRYIRRDE | ADINTFIYMA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rabbit
Rat
ELISA Kit for Mouse CUL-5
ELISA Kit for Mouse CUL-5
ELISA Kit for Mouse CUL-5
ELISA Kit for Mouse CUL-5
Polyclonal Antibody for Mouse CUL-5
Polyclonal Antibody for Mouse CUL-5
Polyclonal Antibody for Mouse CUL-5
Polyclonal Antibody for Mouse CUL-5
Monoclonal Antibody for Mouse CUL-5
Monoclonal Antibody for Mouse CUL-5
Monoclonal Antibody for Mouse CUL-5
Monoclonal Antibody for Mouse CUL-5
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Brain .
tissue :
Medulla oblongata .
tissue :
Ovary .
tissue :
Testis .
tissue :
Uterus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Olfactory epithelium .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-384;FUNCTION